The article is devoted to the history of formation of medical microbiology in Tsarist Russia. Since 1885 the first enthusiasts of «germ theory» in Russia with supporting of science patrons began to develop it in Odessa and St. Petersburg. The particular international type of scientific culture, which was embodied in the activity of bacteriological laboratories, is formed, but it had the local peculiarities. The microorganisms’ investigations in Russia at the end of 1880s were far from the interests of physicians.
