The author of the article, based on archival materials, examines the anti-religious campaign against the Russian Orthodox Church and the Orthodox on the territory of the Saratov Volga region in the late 1920s – early 1940s. The anti-religious campaign was carried out in the form of repressions against worshipers and believers, the seizure of temples and houses of worship, anti-religious agitation and propaganda, and other anti-religious events.